Novel Agents against Miltefosine-Unresponsive Leishmania donovani.
نویسندگان
چکیده
Visceral leishmaniasis is a deadly endemic disease. Unresponsiveness to the only available oral drug miltefosine poses a big challenge for the chemotherapy of the disease. We report a novel molecule, PS-203 {4-(4,4,8-trimethyl-7-oxo-3-oxabicyclo[3.3.1]non-2-yl)-benzoic acid methyl ester}, as effective against a miltefosine-unresponsive strain of the parasite. Further, combinations of PS-203 with miltefosine were also evaluated and showed promising results against a miltefosine-unresponsive strain.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 59 12 شماره
صفحات -
تاریخ انتشار 2015